Journal of dermatological science, 2015-04, Vol.78 (1), p.67-75
2015
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Details
- Autor(en) / Beteiligte
- Titel
- Identification of HSP70-inducing activity in Arnica montana extract and purification and characterization of HSP70-inducers
- Ist Teil von
- Journal of dermatological science, 2015-04, Vol.78 (1), p.67-75
- Ort / Verlag
- Netherlands: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We here searched for HSP70-inducers from a library of herbal extracts that have already been approved as quasi-pharmaceutical products in Japan. • We selected an ethanol extract of Arnica montana and purified an HSP70-inducer, AM-2 (helenalin 2-methylbutyrate). • Pre-treatment of cells with AM-2 or Arnica montana extract decreased melanin production. • These results suggest that AM-2 and Arnica montana extract could be beneficial for use in hypopigmenting cosmetics as a consequence of their stimulatory effects on HSP70 expression.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0923-1811eISSN: 1873-569XDOI: 10.1016/j.jdermsci.2015.01.014Titel-ID: cdi_proquest_miscellaneous_1669838316
- Format
- –
- Schlagworte
- Animals, Arnica - chemistry, Arnica montana, Cell Line, Tumor, Cell Survival - drug effects, Dermatology, Dose-Response Relationship, Drug, Ethanol - chemistry, Heat shock protein 70, HSP70 Heat-Shock Proteins - metabolism, Hypopigmenting cosmetics, Melanins - biosynthesis, Melanogenesis, Melanoma, Experimental, Mice, Monophenol Monooxygenase - metabolism, Photo-aging, Phytotherapy, Plant Extracts - chemistry, Plant Extracts - isolation & purification, Plant Extracts - pharmacology, Plants, Medicinal, Skin - drug effects, Skin - metabolism, Skin - pathology, Skin Lightening Preparations - chemistry, Skin Lightening Preparations - isolation & purification, Skin Lightening Preparations - pharmacology, Skin Pigmentation - drug effects, Solvents - chemistry, Up-Regulation