Details

Autor(en) / Beteiligte

• Aller, E E J G
• Larsen, T M
• Claus, H
• Lindroos, A K
• Kafatos, A
• Pfeiffer, A
• Martinez, J A
• Handjieva-Darlenska, T
• Kunesova, M
• Stender, S
• Saris, W H M
• Astrup, A
• van Baak, M A

Titel

Weight loss maintenance in overweight subjects on ad libitum diets with high or low protein content and glycemic index: the DIOGENES trial 12-month results

Ist Teil von

• International Journal of Obesity, 2014-12, Vol.38 (12), p.1511-1517

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Background: A high dietary protein (P) content and low glycemic index (LGI) have been suggested to be beneficial for weight management, but long-term studies are scarce. Objective: The DIOGENES randomized clinical trial investigated the effect of P and GI on weight loss maintenance in overweight or obese adults in eight centers across Europe. This study reports the 1-year results in two of the centers that extended the intervention to 1 year. Method: After an 8-week low-calorie diet (LCD), 256 adults (body mass index >27 kg m − 2 ) were randomized to five ad libitum diets for 12 months: high P/LGI (HP/LGI), HP/high GI (HP/HGI), low P/LGI (LP/LGI), LP/HGI and a control diet. During the first 6 months, foods were provided for free through a shop system and during the whole 12-month period, subjects received guidance by a dietician. Primary outcome variable was the change in body weight over the 12-month intervention period. Results: During the LCD period, subjects lost 11.2 (10.8, 12.0) kg (mean (95% confidence interval (CI))). Average weight regain over the 12-month intervention period was 3.9 (95% CI 3.0–4.8) kg. Subjects on the HP diets regained less weight than subjects on the LP diets. The difference in weight regain after 1 year was 2.0 (0.4, 3.6) kg ( P =0.017) (completers analysis, N =139) or 2.8 (1.4, 4.1) kg ( P <0.001) (intention-to-treat analysis, N =256). No consistent effect of GI on weight regain was found. There were no clinically relevant differences in changes in cardiometabolic risk factors among diet groups. Conclusion: A higher protein content of an ad libitum diet improves weight loss maintenance in overweight and obese adults over 12 months.