Behavioral neuroscience, 1994-02, Vol.108 (1), p.177-185
1994
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- Autor(en) / Beteiligte
- Titel
- Hypoalgesia in Response to Sensitization During Acute Noise Stress
- Ist Teil von
- Behavioral neuroscience, 1994-02, Vol.108 (1), p.177-185
- Ort / Verlag
- Washington, DC: American Psychological Association
- Erscheinungsjahr
- 1994
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Three experiments examined the antinociceptive response shown by rats during exposure to loud noise. Noise exposure resulted in a time-dependent elevation of radiant heat tail flick latency that varied as a function of stimulus intensity. Noise stress hypoalgesia in response to a 90-dB stimulus was blocked by pretreatment with the opioid antagonist naltrexone (0.1-7.0 mg/kg). Systemic administration of midazolam (2 mg/kg) prior to exposure to the stressor attenuated the elevation in tail flick latency. Because topographically similar antinociceptive responses may be elicited with a low intensity noise stimulus that has served as a Pavlovian conditional stimulus for shock, the use of this paradigm may permit direct comparisons of associative and nonassociative fear responses using qualitatively similar auditory stimuli.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0735-7044eISSN: 1939-0084DOI: 10.1037/0735-7044.108.1.177Titel-ID: cdi_proquest_miscellaneous_16681064
- Format
- –
- Schlagworte
- Acoustic Stimulation, Animal, Animal behavior, Animals, Arousal - drug effects, Arousal - physiology, Association Learning - drug effects, Association Learning - physiology, Attention - drug effects, Attention - physiology, Auditory Stimulation, Behavioral psychophysiology, Biological and medical sciences, Conditioning, Classical - drug effects, Conditioning, Classical - physiology, Fear - drug effects, Fear - physiology, Fundamental and applied biological sciences. Psychology, Loudness Perception - drug effects, Loudness Perception - physiology, Male, Midazolam - pharmacology, Miscellaneous, Naltrexone, Naltrexone - pharmacology, Nociceptors - drug effects, Nociceptors - physiology, Noise, Noise - adverse effects, Pain Perception, Pain Threshold - drug effects, Pain Threshold - physiology, Psychology. Psychoanalysis. Psychiatry, Psychology. Psychophysiology, Rats, Reaction Time - drug effects, Reaction Time - physiology, Receptors, Opioid - drug effects, Receptors, Opioid - physiology, Rodents, Stimulus Intensity, Stress, Tail - innervation, Thermosensing - drug effects, Thermosensing - physiology