Details

Autor(en) / Beteiligte

• Del Buffa, Stefano
• Bonini, Massimo
• Ridi, Francesca
• Severi, Mirko
• Losi, Paola
• Volpi, Silvia
• Al Kayal, Tamer
• Soldani, Giorgio
• Baglioni, Piero

Titel

Design and characterization of a composite material based on Sr(II)-loaded clay nanotubes included within a biopolymer matrix

Ist Teil von

• Journal of colloid and interface science, 2015-06, Vol.448, p.501-507

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• [Display omitted] This paper reports on the preparation, characterization, and cytotoxicity of a hybrid nanocomposite material made of Sr(II)-loaded Halloysite nanotubes included within a biopolymer (3-polyhydroxybutyrate-co-3-hydroxyvalerate) matrix. The Sr(II)-loaded inorganic scaffold is intended to provide mechanical resistance, multi-scale porosity, and to favor the in-situ regeneration of bone tissue thanks to its biocompatibility and bioactivity. The interaction of the hybrid system with the physiological environment is mediated by the biopolymer coating, which acts as a binder, as well as a diffusional barrier to the Sr(II) release. The degradation of the polymer progressively leads to the exposure of the Sr(II)-loaded Halloysite scaffold, tuning its interaction with osteogenic cells. The in vitro biocompatibility of the composite was demonstrated by cytotoxicity tests on L929 fibroblast cells. The results indicate that this composite material could be of interest for multiple strategies in the field of bone tissue engineering.