Details

Autor(en) / Beteiligte

• Maillard, F
• Manouvrier, S
• Biardeau, X
• Ouzzane, A
• Villers, A

Titel

Lynch syndrome and risk of prostate cancer; review of the literature

Ist Teil von

• Progrès en urologie (Paris), 2015-04, Vol.25 (5), p.225-232

Ort / Verlag

France

Erscheinungsjahr

2015

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The association between Lynch syndrome and prostate cancer has been studied. Recent studies report an association between these two diseases. Literature review based on PubMed search was performed using the following keywords: Lynch syndrome and prostate cancer. Eight articles analyzing cohorts of subjects carrying Lynch syndrome were analysed including 6786 patients with 175 cancers. Prostate cancers were more frequent with a standardized incidence ratio (SIR) from 0.93 (95% CI: 0.19-2.7) and 5.9 (95% CI 4.1-17.1) and occurs at a younger age than in the general population mainly for mutations in the MSH2 gene. Prostate cancer seem more frequent and occur earlier in individuals harboring a mutation in the MSH2 gene while it does not appear to be any difference compared to the general population for other mutations in Lynch syndrome.