Details

Autor(en) / Beteiligte

• Petersen, Lene M
• Holm, Dorte K
• Knudsen, Peter B
• Nielsen, Kristian F
• Gotfredsen, Charlotte H
• Mortensen, Uffe H
• Larsen, Thomas O

Titel

Characterization of four new antifungal yanuthones from Aspergillus niger

Ist Teil von

• Journal of antibiotics, 2015-03, Vol.68 (3), p.201-205

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Four new yanuthone analogs ( 1–4 ) were isolated from the filamentous fungus Aspergillus niger . The structures of the new compounds were elucidated on the basis of UHPLC-DAD-HRMS data and one-dimensional and two-dimensional NMR spectroscopy. Labeling studies with 13 C 8 -6-methylsalicylic acid identified three class I yanuthones originating from the polyketide 6-methylsalicylic acid (yanuthone K, L and M ( 1–3 )) and a class II yanuthone, which was named yanuthone X 2 ( 4 ). The four new compounds were tested toward the pathogenic yeast Candida albicans and all displayed antifungal activity. Yanuthone X 2 represents the first example of a bioactive class II yanuthone, demonstrating the pharmaceutical potential of this class.