Details

Autor(en) / Beteiligte

• Dontschuk, Nikolai
• Stacey, Alastair
• Tadich, Anton
• Rietwyk, Kevin J
• Schenk, Alex
• Edmonds, Mark T
• Shimoni, Olga
• Pakes, Chris I
• Prawer, Steven
• Cervenka, Jiri

Titel

A graphene field-effect transistor as a molecule-specific probe of DNA nucleobases

Ist Teil von

• Nature communications, 2015-03, Vol.6 (1), p.6563-6563, Article 6563

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Fast and reliable DNA sequencing is a long-standing target in biomedical research. Recent advances in graphene-based electrical sensors have demonstrated their unprecedented sensitivity to adsorbed molecules, which holds great promise for label-free DNA sequencing technology. To date, the proposed sequencing approaches rely on the ability of graphene electric devices to probe molecular-specific interactions with a graphene surface. Here we experimentally demonstrate the use of graphene field-effect transistors (GFETs) as probes of the presence of a layer of individual DNA nucleobases adsorbed on the graphene surface. We show that GFETs are able to measure distinct coverage-dependent conductance signatures upon adsorption of the four different DNA nucleobases; a result that can be attributed to the formation of an interface dipole field. Comparison between experimental GFET results and synchrotron-based material analysis allowed prediction of the ultimate device sensitivity, and assessment of the feasibility of single nucleobase sensing with graphene.