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Antagonist of Prostaglandin E2 Receptor 4 Induces Metabolic Alterations in Liver of Mice
Ist Teil von
Journal of proteome research, 2015-03, Vol.14 (3), p.1566-1573
Ort / Verlag
United States: American Chemical Society
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
Prostaglandin E2 receptor 4 (EP4) is one of the receptors for prostaglandin E2 and plays important roles in various biological functions. EP4 antagonists have been used as anti-inflammatory drugs. To investigate the effects of an EP4 antagonist (L-161982) on the endogenous metabolism in a holistic manner, we employed a mouse model, and obtained metabolic and transcriptomic profiles of multiple biological matrixes, including serum, liver, and urine of mice with and without EP4 antagonist (L-161982) exposure. We found that this EP4 antagonist caused significant changes in fatty acid metabolism, choline metabolism, and nucleotide metabolism. EP4 antagonist exposure also induced oxidative stress to mice. Our research is the first of its kind to report information on the alteration of metabolism associated with an EP4 antagonist. This information could further our understanding of current and new biological functions of EP4.