Organic letters, 2015-03, Vol.17 (5), p.1146-1149
2015
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- New Duclauxamide from Penicillium manginii YIM PH30375 and Structure Revision of the Duclauxin Family
- Ist Teil von
- Organic letters, 2015-03, Vol.17 (5), p.1146-1149
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Duclauxamide A1 (1), a new polyketide-derived heptacyclic oligophenalenone dimer with a N-2-hydroxyethyl moiety, was isolated from Penicillium manginii YIM PH30375. Spectroscopic analysis, X-ray single crystal diffraction, and 13C NMR DFT calculations confirmed that compound 1 and other duclauxin analogues possess the unified S configuration at C-9′, which corrects a long-standing misrepresentation of duclauxins as C-9′R epimers. A plausible biosynthetic pathway for duclauxins is proposed on the basis of previous acetate labeling results for duclauxin and sclerodin.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1523-7060eISSN: 1523-7052DOI: 10.1021/acs.orglett.5b00081Titel-ID: cdi_proquest_miscellaneous_1661325433
- Format
- –
- Schlagworte
- Antineoplastic Agents - chemistry, Antineoplastic Agents - isolation & purification, Antineoplastic Agents - pharmacology, Chromones - chemistry, Crystallography, X-Ray, Drug Screening Assays, Antitumor, HL-60 Cells, Humans, Molecular Conformation, Molecular Structure, Nuclear Magnetic Resonance, Biomolecular, Penicillium - chemistry, Polyketides - chemistry, Polyketides - isolation & purification, Polyketides - pharmacology