International journal of medical microbiology, 2015-02, Vol.305 (2), p.276-282
2015
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Details
- Autor(en) / Beteiligte
- Titel
- The inverse autotransporter family: Intimin, invasin and related proteins
- Ist Teil von
- International journal of medical microbiology, 2015-02, Vol.305 (2), p.276-282
- Ort / Verlag
- Germany: Elsevier GmbH
- Erscheinungsjahr
- 2015
- Quelle
- Access via ScienceDirect (Elsevier)
- Beschreibungen/Notizen
- Abstract Intimin and invasin are adhesins and central virulence factors of attaching and effacing bacteria, such as enterohaemorrhagic Escherichia coli , and enteropathogenic Yersiniae , respectively. These proteins are prototypes of a large family of adhesins distributed widely in Gram-negative bacteria. It is now evident that this protein family represents a previously unrecognized autotransporter secretion system, termed type Ve secretion. In contrast to classical autotransport, where the transmembrane β-barrel domain or translocation unit is C-terminal to the extracellular region or passenger domain, type Ve-secreted proteins have an inverted topology with the passenger domain C-terminal to the translocation unit; hence the term inverse autotransporter. This minireview covers the recent advances in elucidating the structure and biogenesis of inverse autotransporters.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1438-4221eISSN: 1618-0607DOI: 10.1016/j.ijmm.2014.12.011Titel-ID: cdi_proquest_miscellaneous_1660421189
- Format
- –
- Schlagworte
- Adhesins, Bacterial - chemistry, Adhesins, Bacterial - metabolism, Autotransport, Bacterial adhesion, Escherichia coli Proteins - chemistry, Escherichia coli Proteins - metabolism, Gram-Negative Bacteria - chemistry, Gram-Negative Bacteria - metabolism, Infectious Disease, Intimin, Invasin, Medical Education, Membrane Transport Proteins - chemistry, Membrane Transport Proteins - metabolism, Models, Molecular, Protein Conformation, Protein Multimerization, Protein Structure, Tertiary, Protein Transport, Type Ve secretion, Virulence Factors - chemistry, Virulence Factors - metabolism