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Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats
Journal of neuroscience research, 2015-04, Vol.93 (4), p.666-677
Sun, Yan-Na
Liu, Li-Bo
Xue, Yi-Xue
Wang, Ping
2015
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Sun, Yan-Na
Liu, Li-Bo
Xue, Yi-Xue
Wang, Ping
Titel
Effects of insulin combined with idebenone on blood-brain barrier permeability in diabetic rats
Ist Teil von
Journal of neuroscience research, 2015-04, Vol.93 (4), p.666-677
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Quelle
MEDLINE
Beschreibungen/Notizen
This study investigates the effect of insulin combined with idebenone on blood–brain barrier (BBB) permeability in experimental streptozotocin‐induced diabetic rats as well as the underlying mechanisms. With a diabetic rat model, we show that insulin and idebenone normalize body weight and water intake and restore BBB permeability and that their combination displays a synergistic effect. The results from transmission electron microscopy show that the combination of insulin and idebenone significantly closed the tight junction (TJ) in diabetic rats. The results from Western blotting in diabetic rats show that the upregulation of TJ‐associated proteins occludin, and zonula occludens (ZO)‐1 caused by the combination of insulin and idebenone is more remarkable than that with either agent alone. In addition, the activations of reactive oxygen species (ROS) and advanced glycation end products (AGEs) and the expression levels of receptors for advanced glycation end‐products (RAGE) and nuclear factor‐κB (NF‐κB) were significantly decreased after treatment with insulin and idebenone in diabetic rats. These results suggest that the combination of insulin and idebenone could decrease the BBB permeability in diabetic rats by upregulating the expression of occludin, claudin‐5, and ZO‐1 and that the ROS/AGE/RAGE/NF‐κB signal pathway might be involved in the process. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 0360-4012
eISSN: 1097-4547
DOI: 10.1002/jnr.23511
Titel-ID: cdi_proquest_miscellaneous_1660415179
Format
–
Schlagworte
Animals
,
Antioxidants - therapeutic use
,
blood-brain barrier
,
Blood-Brain Barrier - drug effects
,
Blood-Brain Barrier - physiopathology
,
Blood-Brain Barrier - ultrastructure
,
Capillary Permeability - drug effects
,
diabetes
,
Diabetes Mellitus, Experimental - chemically induced
,
Diabetes Mellitus, Experimental - drug therapy
,
Diabetes Mellitus, Experimental - pathology
,
Disease Models, Animal
,
Hypoglycemic Agents - therapeutic use
,
idebenone
,
insulin
,
Insulin - therapeutic use
,
Male
,
Microscopy, Electron, Transmission
,
Nucleoproteins - metabolism
,
Rats
,
Rats, Wistar
,
Reactive Oxygen Species - metabolism
,
Statistics, Nonparametric
,
tight junction
,
Ubiquinone - analogs & derivatives
,
Ubiquinone - therapeutic use
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