Details

Autor(en) / Beteiligte

• Chen, Y.T.
• Wu, J.H.
• Tsai, F.J.
• Chang, Y.W.
• Hsu, S.H.
• Lin, J.J.
• Sue, H.L.
• Liao, J.W.

Titel

Genotoxicity tests of poly(styrene-co-maleic anhydride)-coated silver nanoparticles in vivo and in vitro

Ist Teil von

• Journal of experimental nanoscience, 2015-04, Vol.10 (6), p.449-457

Ort / Verlag

Taylor & Francis

Erscheinungsjahr

2015

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Nanosilver is thought to hold potential for use in medical materials. The safety of newly developed poly(styrene-co-maleic anhydride)-coated silver nanoparticles (SMA-AgNPs) requires investigation. In this study, three in vitro and in vivo experiments for investigating genetic toxicity-the Ames test, a micronucleus assay, and a chromosome aberration test-were conducted. Results from the Ames testing showed SMA-AgNPs to have a negative effect, either with or without S9 metabolism. In addition, SMA-AgNPs increased the number of reticulocytes and micronuclei in reticulocytes at 48 and 72 h after treatment. Indeed, SMA-AgNPs induced significant changes in the chromosomal aberration rate in CHO-K1 (Chinese hamster ovary cell clone K1) cells. In conclusion, SMA-AgNPs did cause DNA damage in terms of chromosomal aberration and may have a potential genotoxic effect in certain applications.