Details

Autor(en) / Beteiligte

• da Silva, Victor Hugo Pereira
• de Moura, Carolina Foot Gomes
• Ribeiro, Flavia Andressa Pidone
• Cesar, Augusto
• Pereira, Camilo Dias Seabra
• Silva, Marcelo Jose Dias
• Vilegas, Wagner
• Ribeiro, Daniel Araki

Titel

Genotoxicity and cytotoxicity induced by municipal effluent in multiple organs of Wistar rats

Ist Teil von

• Environmental science and pollution research international, 2014-11, Vol.21 (22), p.13069-13080

Ort / Verlag

Berlin/Heidelberg: Springer Berlin Heidelberg

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• The aim of this study was to evaluate cytotoxicity and genotoxicity in multiple organs of rats induced by municipal effluent released by submarine outfall in city of Santos. A total of 20 male Wistar rats were exposed to effluents by drinking water ad libitum at concentrations of 0, 10, 50, and 100 % for 30 days. Microscopic analysis revealed severe lesions such as necrosis and hemorrhagic areas in liver and kidney from animals exposed to effluent at 50 and 100 % concentration. DNA damage in peripheral blood, liver, and kidney cells were detected by comet assay at higher concentrations of effluent. Moreover, a decrease DNA repair capacity was detected in liver cells. Significant statistical differences ( p  < 0.05) for micronucleated cells from liver were noticed at 50 % concentration of effluent. Taken together, our results demonstrate that municipal effluent is able to induce cytotoxicity and genotoxicity in multiple organs of Wistar rats.