Details

Autor(en) / Beteiligte

• Sebekova, Katarina
• Dusinska, Maria
• Klenovics, Kristina Simon
• Kollarova, Radana
• Boor, Peter
• Kebis, Anton
• Staruchova, Marta
• Vlkova, Barbora
• Celec, Peter
• Hodosy, Julius
• Baciak, Ladislav
• Tuskova, Radka
• Beno, Milan
• Tulinska, Jana
• Pribojova, Jana
• Bilanicova, Dagmar
• Pojana, Giulio
• Marcomini, Antonio
• Volkovova, Katarina

Titel

Comprehensive assessment of nephrotoxicity of intravenously administered sodium-oleatecoated ultra-small superparamagnetic iron oxide (USPIO) and titanium dioxide (TiO sub(2)) nanoparticles in rats

Ist Teil von

• Nanotoxicology, 2014-03, Vol.8 (2), p.142-157

Erscheinungsjahr

2014

Beschreibungen/Notizen

• As a main excretory organ, kidney is predisposed to direct/indirect injury. We addressed the potential nephrotoxic effects following expositions of healthy rats to nanoparticle (NP) loads relevant to humans in a situation of 100% bioavailability. Up to 4 weeks after administration, a single iv bolus of oleate-coated ultra-small superparamagnetic iron oxide NPs (in dose of 0.1%, 1.0% and 10.0% of LD50) or TiO sub(2) NPs (1.0% of LD50) did not elicit decline in renal function, damage to proximal tubules, alterations in: renal histology or expression of pro-inflammatory/profibrotic genes, markers of systemic or local renal micro-inflammation or oxidative damage. Antioxidant enzyme activities in renal cortex, mildly elevated at 24 h, completely restored at later time points. Data obtained by multifaceted approach enable the prediction of human nephrotoxicity during preclinical studies, and may serve as comparison for alternative testing strategies using in vitro and in silico methods essential for the NP-nephrotoxicity risk assessment.