Details

Autor(en) / Beteiligte

• Pownall, Henry J.
• Bray, George A.
• Wagenknecht, Lynne E.
• Walkup, Michael P.
• Heshka, Stanley
• Hubbard, Van S.
• Hill, James
• Kahn, Steven E.
• Nathan, David M.
• Schwartz, Anne V.
• Johnson, Karen C.

Titel

Changes in body composition over 8 years in a randomized trial of a lifestyle intervention: The look AHEAD study

Ist Teil von

• Obesity (Silver Spring, Md.), 2015-03, Vol.23 (3), p.565-572

Ort / Verlag

United States: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• Objective To determine the effects of an intensive lifestyle intervention versus a comparison group on body composition in obese or overweight persons with type 2 diabetes at baseline and at 1, 4, and 8 years. Methods Body composition was measured by dual‐energy X‐ray absorptiometry in a subset of 1019 Look AHEAD study volunteers randomized to intervention or comparison groups. The intervention was designed to achieve and maintain ≥7% weight loss through increased physical activity and reduced caloric intake. The comparison group received social support and diabetes education. Results At 1 year, the intervention group lost fat (5.6 ± 0.2 kg) and lean mass (2.3 ± 0.1 kg) but regained fat (∼100%) and lost lean mass between years 1 and 8. Between baseline and year 8, weight loss was greater in intervention versus comparison groups (4.0 ± 0.4 vs. 2.3 ± 0.4 kg); comparison group weight loss was mostly lean mass (2.1 ± 0.17 kg). Fat mass in the intervention group was lower than that of the comparison group at all post‐baseline time points. Conclusions Reduced fat mass may place the intervention group at a lower risk of obesity‐linked sequelae, a hypothesis that can be tested by future studies of this cohort.