Cancer letters, 2015-04, Vol.359 (2), p.275-287
2015
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- EZH2 promotes tumor progression via regulating VEGF-A/AKT signaling in non-small cell lung cancer
- Ist Teil von
- Cancer letters, 2015-04, Vol.359 (2), p.275-287
- Ort / Verlag
- Ireland: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2015
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights • EZH2, as an independent prognostic factor, correlates positively with VEGF-A. • EZH2 overexpression confers a shorter overall survival time in NSCLC patients. • EZH2 stimulates VEGF-A expression and the aggressiveness of lung cancer cells. • VEGF-A induces AKT phosphorylation without affecting the EZH2 activity. • EZH2 promotes tumor progression via the PI3K/AKT pathway in NSCLC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0304-3835eISSN: 1872-7980DOI: 10.1016/j.canlet.2015.01.031Titel-ID: cdi_proquest_miscellaneous_1657323248
- Format
- –
- Schlagworte
- Adenocarcinoma - metabolism, Adenocarcinoma - pathology, Angiogenesis, Animals, Carcinoma, Non-Small-Cell Lung - metabolism, Carcinoma, Non-Small-Cell Lung - pathology, Carcinoma, Squamous Cell - metabolism, Carcinoma, Squamous Cell - pathology, Cell cycle, Cell growth, Colonies & territories, Disease Progression, Enhancer of Zeste Homolog 2 Protein, Enhancer of Zeste Homologue 2, Female, Gene expression, Hematology, Oncology and Palliative Medicine, Kinases, Lung cancer, Lung Neoplasms - metabolism, Lung Neoplasms - pathology, Male, Medical prognosis, Metastasis, Mice, Inbred BALB C, Mice, Nude, Mortality, Neoplasm Transplantation, Non-small cell lung carcinoma, Phosphorylation, PI3K/AKT signaling, Polycomb Repressive Complex 2 - metabolism, Prognosis, Protein Processing, Post-Translational, Proteins, Proto-Oncogene Proteins c-akt - metabolism, Signal Transduction, Small interfering RNA, Software, Thoracic surgery, Tumor Burden, Vascular endothelial growth factor, Vascular Endothelial Growth Factor A - metabolism, VEGF-A