Details

Autor(en) / Beteiligte

• Jacob, Jesse T
• Chernetsky Tejedor, Sheri
• Dent Reyes, Mary
• Lu, Xin
• Easley, Kirk A
• Aurand, William L
• Garrett, Gina
• Graham, Kimberly
• Holder, Carolyn
• Robichaux, Chad
• Steinberg, James P

Titel

Comparison of a silver-coated needleless connector and a standard needleless connector for the prevention of central line-associated bloodstream infections

Ist Teil von

• Infection control and hospital epidemiology, 2015-03, Vol.36 (3), p.294-301

Ort / Verlag

United States: Cambridge University Press

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• To assess the impact of a novel, silver-coated needleless connectors (NCs) on central-line-associated bloodstream infection (CLABSI) rates compared with a mechanically identical NCs without a silver coating. Prospective longitudinal observation study SETTING Two 500-bed university hospitals All hospitalized adults from November 2009 to June 2011 with non-hemodialysis central lines Hospital A started with silver-coated NCs and switched to standard NCs in September 2010; hospital B started with standard NCs and switched to silver-coated NCs. The primary outcome was the difference revealed by Poisson multivariate regression in CLABSI rate using standard Centers for Disease Control and Prevention surveillance definitions. The secondary outcome was a comparison of organism-specific CLABSI rates by NC type. Among 15,845 hospital admissions, 140,186 central-line days and 221 CLABSIs were recorded during the study period. In a multivariate model, the CLABSI rate per 1,000 central-line days was lower with silver-coated NCs than with standard NCs (1.21 vs 1.79; incidence rate ratio=0.68 [95% CI: 0.52-0.89], P=.005). A lower CLABSI rate per 1,000 central-line days for the silver-coated NCs versus the standard NCs was observed with S. aureus (0.11 vs 0.30, P=.02), enterococci (0.10 vs 0.27, P=.03), and Gram-negative organisms (0.28 vs 0.63, P=.003) but not with coagulase-negative staphylococci (0.31 vs 0.36) or Candida spp. (0.42 vs 0.40). The use of silver-coated NCs decreased the CLABSI rate by 32%. CLABSI reduction efforts should include efforts to minimize contamination of NCs.