Details

Autor(en) / Beteiligte

• Martinez‐Selles, Manuel
• Almenar, Luis
• Paniagua‐Martin, Maria J.
• Segovia, Javier
• Delgado, Juan F.
• Arizón, Jose M.
• Ayesta, Ana
• Lage, Ernesto
• Brossa, Vicens
• Manito, Nicolás
• Pérez‐Villa, Félix
• Diaz‐Molina, Beatriz
• Rábago, Gregorio
• Blasco‐Peiró, Teresa
• De La Fuente Galán, Luis
• Pascual‐Figal, Domingo
• Gonzalez‐Vilchez, Francisco

Titel

Donor/recipient sex mismatch and survival after heart transplantation: only an issue in male recipients? An analysis of the Spanish Heart Transplantation Registry

Ist Teil von

• Transplant international, 2015-03, Vol.28 (3), p.305-313

Ort / Verlag

England: Blackwell Publishing Ltd

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary The results of studies on the association between sex mismatch and survival after heart transplantation are conflicting. Data from the Spanish Heart Transplantation Registry. From 4625 recipients, 3707 (80%) were men. The donor was female in 943 male recipients (25%) and male in 481 female recipients (52%). Recipients of male hearts had a higher body mass index (25.9 ± 4.1 vs. 24.3 ± 3.7; P < 0.01), and male donors were younger than female donors (33.4 ± 12.7 vs. 38.2 ± 12.3; P < 0.01). No further relevant differences related to donor sex were detected. In the univariate analysis, mismatch was associated with mortality in men (hazard ratio [HR], 1.18; 95% confidence interval [CI], 1.06–1.32; P = 0.003) but not in women (HR, 0.91; 95% CI 0.74–1.12; P = 0.4). A significant interaction was detected between sex mismatch and recipient gender (P = 0.02). In the multivariate analysis, sex mismatch was associated with long‐term mortality (HR, 1.14; 95% CI 1.01–1.29; P = 0.04), and there was a tendency toward significance for the interaction between sex mismatch and recipient gender (P = 0.08). In male recipients, mismatch increased mortality mainly during the first month and in patients with pulmonary gradient >13 mmHg. Sex mismatch seems to be associated with mortality after heart transplantation in men but not in women.