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Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid
Pest management science, 2013-05, Vol.69 (5), p.607-619
Cutler, Penny
Slater, Russell
Edmunds, Andrew JF
Maienfisch, Peter
Hall, Roger G
Earley, Fergus GP
Pitterna, Thomas
Pal, Sitaram
Paul, Verity‐Laura
Goodchild, Jim
Blacker, Melissa
Hagmann, Leonhard
Crossthwaite, Andrew J
2013
Details
Autor(en) / Beteiligte
Cutler, Penny
Slater, Russell
Edmunds, Andrew JF
Maienfisch, Peter
Hall, Roger G
Earley, Fergus GP
Pitterna, Thomas
Pal, Sitaram
Paul, Verity‐Laura
Goodchild, Jim
Blacker, Melissa
Hagmann, Leonhard
Crossthwaite, Andrew J
Titel
Investigating the mode of action of sulfoxaflor: a fourth‐generation neonicotinoid
Ist Teil von
Pest management science, 2013-05, Vol.69 (5), p.607-619
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
2013
Link zum Volltext
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
BACKGROUND: The precise mode of action of sulfoxaflor, a new nicotinic acetylcholine receptor‐modulating insecticide, is unclear. A detailed understanding of the mode of action, especially in relation to the neonicotinoids, is essential for recommending effective pest management practices. RESULTS: Radiolabel binding experiments using a tritiated analogue of sulfoxaflor ([³H]‐methyl‐SFX) performed on membranes from Myzus persicae demonstrate that sulfoxaflor interacts specifically with the high‐affinity imidacloprid binding site present in a subpopulation of the total nAChR pool. In competition studies, imidacloprid‐like neonicotinoids displace [³H]‐methyl‐SFX at pM concentrations. The effects of sulfoxaflor on the exposed aphid nervous system in situ are analogous to those of imidacloprid and nitenpyram, and finally the high‐affinity sulfoxaflor binding site is absent in a Myzus persicae strain (clone FRC) possessing a single amino acid point mutation (R81T) in the β‐nAChR, a region critical for neonicotinoid interaction. CONCLUSION: The nicotinic acetylcholine receptor pharmacological profile of sulfoxaflor in aphids is consistent with that of imidacloprid. Additionally, the insecticidal activity of sulfoxaflor and the current commercialised neonicotinoids is affected by the point mutation in FRC Myzus persicae. Therefore, it is suggested that sulfoxalfor be considered a neonicotinoid, and that this be taken into account when recommending insecticide rotation partnering for effective resistance management programmes. © 2012 Society of Chemical Industry
Sprache
Englisch
Identifikatoren
ISSN: 1526-498X
eISSN: 1526-4998
DOI: 10.1002/ps.3413
Titel-ID: cdi_proquest_miscellaneous_1654669993
Format
–
Schlagworte
Animals
,
Aphididae
,
Aphids
,
Binding sites
,
Binding, Competitive
,
Biological and medical sciences
,
Control
,
Fundamental and applied biological sciences. Psychology
,
Imidacloprid
,
insecticidal properties
,
Insecticide Resistance
,
Insecticides
,
Insecticides - toxicity
,
Insects
,
mechanism of action
,
Mutation
,
Myzus persicae
,
nervous system
,
nicotinic acetylcholine receptor
,
nitenpyram
,
Pest control
,
pest management
,
Phytopathology. Animal pests. Plant and forest protection
,
point mutation
,
Protozoa. Invertebrates
,
Pyridines - chemical synthesis
,
Pyridines - toxicity
,
radiolabel
,
Receptors, Nicotinic - chemistry
,
resistance
,
resistance management
,
Sulfur Compounds - chemical synthesis
,
Sulfur Compounds - toxicity
,
Tritium
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