Environmental toxicology and pharmacology, 2015-01, Vol.39 (1), p.358-368
2015
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- Autor(en) / Beteiligte
- Titel
- Differential expression of CYP1A1 and CYP1A2 genes in H4IIE rat hepatoma cells exposed to TCDD and PAHs
- Ist Teil von
- Environmental toxicology and pharmacology, 2015-01, Vol.39 (1), p.358-368
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2015
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • TCDD induce Cyp1a1 > Cyp1a2 > Cyp1b1 gene expression profile in H4IIE cells. • PAHs induce Cyp1a2 > Cyp1a1 > Cyp1b1 gene expression profile in H4IIE cells. • PAHs-containing environmental mixtures induce PAHs-specific gene expression. • PAHs-specific gene expression profile is not confirmed in simple low-dose mixtures. • Effect of TCDD and/or PAHs mixture is higher than the pooled single responses.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1382-6689eISSN: 1872-7077DOI: 10.1016/j.etap.2014.11.031Titel-ID: cdi_proquest_miscellaneous_1653129914
- Format
- –
- Schlagworte
- Animals, Carcinoma, Hepatocellular - genetics, Cell Line, Tumor, CYP, Cytochrome P-450 CYP1A1 - genetics, Cytochrome P-450 CYP1A2, Cytochrome P-450 CYP1B1 - genetics, Cytochromes - genetics, Emergency, Gene expression, Gene Expression Regulation, Enzymologic - drug effects, Gene Expression Regulation, Neoplastic - drug effects, Glutathione S-Transferase pi - genetics, Glutathione Transferase - genetics, H4IIE, Isoenzymes - genetics, Liver Neoplasms - genetics, Mixtures, PAHs, Polychlorinated Dibenzodioxins - toxicity, Polycyclic Aromatic Hydrocarbons - toxicity, Rats, TCDD