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Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood
Pediatric pulmonology, 2015-02, Vol.50 (2), p.155-163
Kim, Ja Hyeong
Jeong, Kyoung-Sook
Ha, Eun-Hee
Park, Hyesook
Ha, Mina
Hong, Yun-Chul
Bhang, Soo-Young
Lee, Soo-Jeong
Lee, Kyung-Yeon
Lee, Seon-Ho
Kim, Yangho
Kim, Min-Ho
Chang, Namsoo
2015
Details
Autor(en) / Beteiligte
Kim, Ja Hyeong
Jeong, Kyoung-Sook
Ha, Eun-Hee
Park, Hyesook
Ha, Mina
Hong, Yun-Chul
Bhang, Soo-Young
Lee, Soo-Jeong
Lee, Kyung-Yeon
Lee, Seon-Ho
Kim, Yangho
Kim, Min-Ho
Chang, Namsoo
Titel
Relationship between prenatal and postnatal exposures to folate and risks of allergic and respiratory diseases in early childhood
Ist Teil von
Pediatric pulmonology, 2015-02, Vol.50 (2), p.155-163
Ort / Verlag
United States: Blackwell Publishing Ltd
Erscheinungsjahr
2015
Link zum Volltext
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
Summary Background It is uncertain whether folate is risk or preventive factor for allergic and respiratory diseases. Objective To determine the relationship between maternal or offspring folate status and subsequent development of allergic and respiratory diseases in early childhood. Methods In total, 917 mother‐child pairs from a prospective birth cohort in South Korea were studied. Data regarding the children's allergic and respiratory outcomes were obtained from standardized questionnaires completed by the mothers at postnatal months 6, 12, and 24. Serum folate levels were measured in the mothers at mid‐ and late‐pregnancy, and in their children at 24 months of age. Atopic biomarkers were measured in the cord blood (CB) and at 24 months after birth. Biomarkers and clinical outcomes were analyzed and compared between the mother‐child pairs divided into two groups according to median serum folate status at mid‐ and late‐pregnancy. Results Serum folate levels during mid‐pregnancy were inversely associated with CB eosinophil count (adjusted odds ratio [OR] 0.72, 95% confidence interval [CI], 0.54–0.96) and positively associated with CB interleukin‐10 levels (1.47, 1.11‐1.94). Maternal folate level above the median value (≥9.5 ng/ml) during mid‐pregnancy was associated with a decreased risk for the child of lower respiratory tract infections (LRTIs) at 6 months of age (adjusted OR 0.50, 95% CI 0.28‐0.91) and atopic dermatitis (AD) at 24 months (adjusted OR 0.52, 95% CI 0.31–0.88), but not with LRTIs and AD at other ages. Conclusions A relatively high maternal serum folate level in mid‐pregnancy was associated with a decreased risk of LRTIs and AD in early childhood. Pediatr Pulmonol. 2015; 50:155–163. © 2014 Wiley Periodicals, Inc.
Sprache
Englisch
Identifikatoren
ISSN: 8755-6863
eISSN: 1099-0496
DOI: 10.1002/ppul.23025
Titel-ID: cdi_proquest_miscellaneous_1652437740
Format
–
Schlagworte
Adult
,
allergic disease
,
Biomarkers
,
Biomarkers - blood
,
Cell Count
,
Child, Preschool
,
Cohort Studies
,
Confidence intervals
,
cord blood
,
Dermatitis, Atopic - blood
,
Dermatitis, Atopic - epidemiology
,
Eosinophils - metabolism
,
Female
,
Fetal Blood - cytology
,
folate
,
Folic Acid - blood
,
Humans
,
Infant
,
Infant, Newborn
,
Interleukin-10 - blood
,
lower respiratory tract infections
,
Male
,
Pregnancy
,
Republic of Korea - epidemiology
,
Respiratory diseases
,
Respiratory Tract Infections - blood
,
Respiratory Tract Infections - epidemiology
,
Risk
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