Medical hypotheses, 2014-12, Vol.83 (6), p.726-729
2014
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- Autor(en) / Beteiligte
- Titel
- Should we be more cautious about replacement of vitamin B12 in patients with cancer receiving cytotoxic chemotherapy?
- Ist Teil von
- Medical hypotheses, 2014-12, Vol.83 (6), p.726-729
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract Vitamin B12 (Cbl) deficiency may cause hematologic and neurologic dysfunction. Replacement therapy is effective in correcting hematologic abnormalities and improving neurologic symptoms. Cbl is known to have antioxidant activity. This antioxidant activity may antagonize the effects of chemotherapeutics (i.e. genotoxic effects of paclitaxel) on tumor DNA. We claim that Cbl replacement should be done more cautiously in patients receiving cytotoxic chemotherapy.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-9877eISSN: 1532-2777DOI: 10.1016/j.mehy.2014.09.027Titel-ID: cdi_proquest_miscellaneous_1652433951
- Format
- –
- Schlagworte
- Antineoplastic Agents - adverse effects, Antineoplastic Agents - therapeutic use, Antioxidants - chemistry, DNA, Neoplasm - metabolism, Drug Interactions, Free Radicals - chemistry, Humans, Internal Medicine, Neoplasms - complications, Neoplasms - drug therapy, Nervous System Diseases - etiology, Nervous System Diseases - prevention & control, Vitamin B 12 - adverse effects, Vitamin B 12 - therapeutic use, Vitamin B 12 Deficiency - blood