Cancer treatment reviews, 2014-12, Vol.40 (10), p.1182-1191
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Improving chemoradiation efficacy by PI3-K/AKT inhibition
- Ist Teil von
- Cancer treatment reviews, 2014-12, Vol.40 (10), p.1182-1191
- Ort / Verlag
- Kidlington: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Highlights • Hypoxia is an inherent negative factor for outcome after chemo- and radio-therapy. • PI3-K/AKT signaling affects hypoxia via HIF-1-dependent & -independent mechanisms. • PI3-K/AKT blockers act synergistic with chemo- or radio-therapy in animal models. • Reduction of hypoxia by PI3-K/AKT blockers seems important for tumor sensitization. • Phase I trials show the feasibility of combining AKT inhibition with chemoradiation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0305-7372eISSN: 1532-1967DOI: 10.1016/j.ctrv.2014.09.005Titel-ID: cdi_proquest_miscellaneous_1652420400
- Format
- –
- Schlagworte
- Animals, Antineoplastic agents, Biological and medical sciences, Biomarkers, Tumor - analysis, Cell Hypoxia - drug effects, Chemoradiotherapy - methods, Chemotherapy, Clinical Trials as Topic, Disease Models, Animal, Drug Resistance, Neoplasm, Hematology, Oncology and Palliative Medicine, HIF-1 signaling, Humans, Hypoxia, Medical sciences, Molecular Targeted Therapy - methods, Neoplasms - drug therapy, Neoplasms - metabolism, Neoplasms - radiotherapy, Pharmacology. Drug treatments, Phosphatidylinositol 3-Kinases - antagonists & inhibitors, PI3-K/AKT inhibition, Proto-Oncogene Proteins c-akt - antagonists & inhibitors, Proto-Oncogene Proteins c-akt - metabolism, Radiotherapy, Signal Transduction, Treatment Outcome