UB Paderborn / Katalog / Suche / Details

Cancer letters, 2015-03, Vol.358 (1), p.47-58

2015

Autor(en) / Beteiligte

Titel

Mitofusin-2 triggers mitochondria Ca2+ influx from the endoplasmic reticulum to induce apoptosis in hepatocellular carcinoma cells

Ist Teil von

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

Highlights • Mfn2 immunostaining is significantly associated with tumour size and TNM stage. • Patients with HCC with lower Mfn2 expression had a poorer prognosis. • Mfn2 induces cells apoptosis, declined ER Ca2+ , and elevated mitochondrial Ca2+. • Heparin and RU360 can changeover the above results. • Mfn2 downregulates the expresion of MICU1 and MICU2.

Sprache: Englisch
Identifikatoren: ISSN: 0304-3835
eISSN: 1872-7980
DOI: 10.1016/j.canlet.2014.12.025
Titel-ID: cdi_proquest_miscellaneous_1652418119

Format: –
Schlagworte: Adenoviruses, Aged, Apoptosis, Apoptosis - genetics, Calcium - metabolism, Carcinoma, Hepatocellular - genetics, Carcinoma, Hepatocellular - metabolism, Carcinoma, Hepatocellular - pathology, Cytochrome, Endoplasmic Reticulum - genetics, Endoplasmic Reticulum - metabolism, Endoplasmic Reticulum - pathology, Female, Gene Expression Regulation, Neoplastic - drug effects, GTP Phosphohydrolases - antagonists & inhibitors, GTP Phosphohydrolases - biosynthesis, Hematology, Oncology and Palliative Medicine, Hep G2 Cells, Heparin, Heparin - administration & dosage, Homeostasis, Humans, InsP3R, Liver cancer, Liver Neoplasms - metabolism, Liver Neoplasms - pathology, Male, Middle Aged, Mitochondria, Mitochondria - pathology, Mitochondrial Ca2+ uniporter, Mitochondrial calcium uptake 2, Mitochondrial calcium uptake1, Mitochondrial Proteins - antagonists & inhibitors, Mitochondrial Proteins - biosynthesis, Neoplasm Staging, Proteins, Reactive Oxygen Species - metabolism, RU360, Ruthenium Compounds - administration & dosage

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