Trends in neurosciences (Regular ed.), 2014-12, Vol.37 (12), p.721-732
2014
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- Autor(en) / Beteiligte
- Titel
- Lost after translation: missorting of Tau protein and consequences for Alzheimer disease
- Ist Teil von
- Trends in neurosciences (Regular ed.), 2014-12, Vol.37 (12), p.721-732
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • Somatodendritic missorting of Tau is an early key event in Alzheimer disease. • Missorting of Tau in neurons can be induced by cell stress (Aβ, glutamate, etc.). • Tau missorting causes microtubule severing by spastin, traffic jams, and synapse loss. • Tau-based therapy is promising because Tau pathology is reversible in disease models.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0166-2236eISSN: 1878-108XDOI: 10.1016/j.tins.2014.08.004Titel-ID: cdi_proquest_miscellaneous_1652407577
- Format
- –
- Schlagworte
- Alzheimer Disease - metabolism, Alzheimer Disease - pathology, Alzheimer's disease, Animals, Axons - metabolism, Axons - pathology, Cytoskeleton, Cytoskeleton - metabolism, Cytoskeleton - pathology, Disease Models, Animal, Humans, Neurology, Neurons, Neurons - metabolism, Neurons - pathology, Neurosciences, Phosphorylation, tau Proteins - genetics, tau Proteins - metabolism