Details

Autor(en) / Beteiligte

• Gomes, M.B
• Negrato, C.A
• Calliari, L.E.P

Titel

Early age at menarche: A risk factor for overweight or obesity in patients with type 1 diabetes living in urban areas?

Ist Teil von

• Diabetes research and clinical practice, 2015-01, Vol.107 (1), p.23-30

Ort / Verlag

Ireland: Elsevier Ireland Ltd

Erscheinungsjahr

2015

Quelle

Access via ScienceDirect (Elsevier)

Beschreibungen/Notizen

• Abstract Aims Determine the relationship between age at menarche, glycemic control and cardiovascular risk factors in patients with type 1 diabetes living in urban areas. Methods This was a multicenter cross-sectional study conducted in 20 cities in four Brazilian geographic regions. Data were obtained from 1527 female patients, 59.3% Caucasians, aged 25.1 ± 10.6 years. Diabetes duration was 11.4 ± 8.1 years. Age at menarche was stratified in four groups: 8–11 (group 1, early menarche), 12 (group 2), 13 (group 3) and 14–18 years (group 4, late menarche). Results The mean age at menarche was 12.7 ± 1.7 years without difference among geographical regions, economic status, level of care and ethnicity. BMI had an inverse correlation with age at menarche ( r = −0.14, p < 0.001). No significant difference was observed among the four groups for blood pressure, lipid profile and diabetes-related chronic complications. Logistic regression analysis showed that early age at menarche, 8–11 years (odds ratio (ORs) 1.77 [1.30–2.41], p < 0.001) and duration of diabetes [ORs 1.01 (1.00–1.03), p = 0.02], were related to greater risk of patients’ overweight or obesity; adherence to diet [ORs 0.78 (0.60–0.93), p = 0.01], physical activity [ORs 0.75 (0.94–0.94), p = 0.01], and lower insulin dose (U/kg) [ORs 0.54 (0.59–0.90), p = 0.001] were related to lower risk for overweight or obesity. Conclusions Early menarche occurred in 23.4% of women with type 1 diabetes living in Brazilian urban areas and was strongly associated with overweight/obesity in pubertal/adult life. Further studies are warranted to establish the relationship between early menarche, glycemic control and cardiovascular risk factors.