Advanced materials (Weinheim), 2014-12, Vol.26 (45), p.7615-7621
2014
Details
- Autor(en) / Beteiligte
- Titel
- Integration of Nanoassembly Functions for an Effective Delivery Cascade for Cancer Drugs
- Ist Teil von
- Advanced materials (Weinheim), 2014-12, Vol.26 (45), p.7615-7621
- Ort / Verlag
- Germany: Blackwell Publishing Ltd
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- Wiley Online Library Journals Frontfile Complete
- Beschreibungen/Notizen
- A “cluster‐bomb”‐like lipid–dendrimer nanoassembly synergizes the functions of its components and thereby efficiently accomplishes the drug delivery cascade for high efficacy in treating cancer. The nanoassembly successfully circulates in the blood and accumulates in the tumor. Once in the tumor, it releases small dendrimers that act like “bomblets”, enabling tumor penetration, cell internalization, and drug release.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0935-9648eISSN: 1521-4095DOI: 10.1002/adma.201401554Titel-ID: cdi_proquest_miscellaneous_1651424342
- Format
- –
- Schlagworte
- Animals, Antineoplastic Agents - administration & dosage, biomedical applications, Blood, Cancer, Cascades, Cell Line, Tumor, Cell Membrane - drug effects, Cell Membrane - metabolism, Cholesterol - chemistry, Clusters, Dendrimers, Doxorubicin - administration & dosage, drug delivery, Drug delivery systems, Drug Delivery Systems - methods, Effectiveness, Female, Humans, lipids, Mice, Mice, Nude, Micelles, nanomedicine, Nanomedicine - methods, Nanostructure, Nanostructures - chemistry, Neoplasms, Experimental - drug therapy, Neoplasms, Experimental - metabolism, Phosphatidylethanolamines - chemistry, Polyethylene Glycols - chemistry, self-assembly, Tumors