The Journal of Antibiotics, 1996/12/25, Vol.49(12), pp.1189-1195
1996
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Details
- Autor(en) / Beteiligte
- Titel
- Nidulal, a Novel Inducer of Differentiation of Human Promyelocytic Leukemia Cells from Nidula Candida
- Ist Teil von
- The Journal of Antibiotics, 1996/12/25, Vol.49(12), pp.1189-1195
- Ort / Verlag
- Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- Erscheinungsjahr
- 1996
- Quelle
- Electronic Journals Library
- Beschreibungen/Notizen
- Nidulal (1), a novel inducer of differentiation of human HL-60 promyelocytic leukemia cells, was isolated from fermentations of the basidiomycete Nidula Candida together with low amounts of niduloic acid (2). Both compounds are bisabolane sesquiterpenes. Their structures were elucidated by spectroscopic methods. In reporter gene assays nidulal (1) preferentially activated the transcription factor complex AP-1 - mediated expression of secreted alkaline phosphatase in COS-7 cells. In addition nidulal (1) and niduloic acid (2) exhibited weak cytotoxic and antibiotic activities.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8820eISSN: 1881-1469DOI: 10.7164/antibiotics.49.1189Titel-ID: cdi_proquest_miscellaneous_16508247
- Format
- –
- Schlagworte
- Alkaline Phosphatase - genetics, Animals, Anti-Bacterial Agents - pharmacology, Antineoplastic agents, Apoptosis, Basidiomycota - metabolism, Biological and medical sciences, Cell Differentiation, Cell Line, Chemotherapy, COS Cells, Cyclohexanecarboxylic Acids - chemistry, Cyclohexanecarboxylic Acids - metabolism, Cyclohexanecarboxylic Acids - pharmacology, DNA Fragmentation, Drug Evaluation, Preclinical, Fungi - drug effects, Furans - chemistry, Furans - metabolism, Furans - pharmacology, HL-60 Cells, Humans, Magnetic Resonance Spectroscopy, Medical sciences, Microbial Sensitivity Tests, Molecular Structure, Mutagenicity Tests, Pharmacology. Drug treatments, Salmonella typhimurium - drug effects, Signal Transduction, Spiro Compounds - chemistry, Spiro Compounds - metabolism, Spiro Compounds - pharmacology, Transcription Factor AP-1 - metabolism, Transcription, Genetic