European neuropsychopharmacology, 2014-11, Vol.24 (11), p.1850-1854
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Reduced cocaine-induced serotonin, but not dopamine and noradrenaline, release in rats with a genetic deletion of serotonin transporters
- Ist Teil von
- European neuropsychopharmacology, 2014-11, Vol.24 (11), p.1850-1854
- Ort / Verlag
- Netherlands: Elsevier B.V
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Abstract It has recently been proposed that the increased reinforcing properties of cocaine and ecstasy observed in rats with a genetic deletion of serotonin transporters are the result of a reduction in the psychostimulant-induced release of serotonin. Here we provide the neurochemical evidence in favor of this hypothesis and show that changes in synaptic levels of dopamine or noradrenaline are not very likely to play an important role in the previously reported enhanced psychostimulant intake of these serotonin transporter knockout rats. The results may very well explain why human subjects displaying a reduced expression of serotonin transporters have an increased risk to develop addiction.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0924-977XeISSN: 1873-7862DOI: 10.1016/j.euroneuro.2014.09.004Titel-ID: cdi_proquest_miscellaneous_1647022286
- Format
- –
- Schlagworte
- Animals, Central Nervous System Stimulants - pharmacology, Cocaine - pharmacology, Dopamine - metabolism, Gene Knockout Techniques, Hippocampus, Hippocampus - drug effects, Hippocampus - metabolism, Internal Medicine, Male, Microdialysis, Norepinephrine - metabolism, Nucleus accumbens, Nucleus Accumbens - drug effects, Nucleus Accumbens - metabolism, Psychiatry, Rats, Serotonin - metabolism, Serotonin - secretion, Serotonin Plasma Membrane Transport Proteins - deficiency, Serotonin Plasma Membrane Transport Proteins - genetics, Serotonin release, Serotonin transporter knockout rats