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The effects of Betula platyphylla bark on amyloid beta-induced learning and memory impairment in mice
Food and chemical toxicology, 2014-12, Vol.74, p.156-163
2014

Details

Autor(en) / Beteiligte
Titel
The effects of Betula platyphylla bark on amyloid beta-induced learning and memory impairment in mice
Ist Teil von
  • Food and chemical toxicology, 2014-12, Vol.74, p.156-163
Ort / Verlag
Oxford: Elsevier Ltd
Erscheinungsjahr
2014
Link zum Volltext
Quelle
Elsevier ScienceDirect Journals
Beschreibungen/Notizen
  • •BPB-316 significantly attenuated Aβ1–42-induced memory impairment by activating the CREB–BDNF pathway.•BPB-316 also inhibited the elevation of β-secretase activity accompanying the reduced Aβ1–42 levels in the hippocampus.•BPB-316 significantly suppressed the AChE activity and recovered the content of GSH in the hippocampus. Alzheimer's disease (AD) is closely associated with amyloid β (Aβ)-induced neurotoxicity and oxidative stress in the brain. Betula platyphylla, which has been used to treat various oxidative-stressed related diseases, has recently received attention for its preventive activity on age-related neurodegenerative diseases. In this study, we attempted to investigate the effects of B. platyphylla bark (BPB-316) on Aβ1–42-induced neurotoxicity and memory impairment. Oral treatment using BPB-316 significantly attenuated Aβ-induced memory impairment which was evaluated by behavioral tests including the passive avoidance, Y-maze and Morris water maze test. BPB-316 also inhibited the elevation of β-secretase activity accompanying the reduced Aβ1–42 levels in the hippocampus of the brain. Furthermore, BPB-316 significantly decreased the acetylcholinesterase activity and increased the glutathione content in the hippocampus. In addition, we confirmed that the expression of both cAMP responsive element-binding protein (CREB) and brain-derived neurotrophic factor (BDNF) in the hippocampus of Aβ1–42-injected mice were markedly upregulated by the treatment of BPB-316. Our data suggest that the extracts of B. platyphylla bark might be a potential therapeutic agent against AD.
Sprache
Englisch
Identifikatoren
ISSN: 0278-6915
eISSN: 1873-6351
DOI: 10.1016/j.fct.2014.09.019
Titel-ID: cdi_proquest_miscellaneous_1647014327
Format
–
Schlagworte
Acetylcholinesterase - metabolism, Adult and adolescent clinical studies, Alzheimer's disease, Amyloid beta, Amyloid beta-Peptides - antagonists & inhibitors, Amyloid beta-Peptides - toxicity, Amyloid Precursor Protein Secretases - biosynthesis, Amyloid Precursor Protein Secretases - genetics, Animals, Aspartic Acid Endopeptidases - biosynthesis, Aspartic Acid Endopeptidases - genetics, Avoidance Learning - drug effects, Behavioral test, Betula - chemistry, Betula platyphylla, Betula platyphylla bark, Biological and medical sciences, Brain-Derived Neurotrophic Factor - metabolism, CREB–BDNF pathway, Cyclic AMP Response Element-Binding Protein - metabolism, Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases, Food toxicology, Glutathione - metabolism, Hippocampus - drug effects, Hippocampus - metabolism, Learning Disorders - chemically induced, Learning Disorders - prevention & control, Learning Disorders - psychology, Male, Maze Learning - drug effects, Medical sciences, Memory Disorders - chemically induced, Memory Disorders - prevention & control, Memory Disorders - psychology, Mice, Mice, Inbred ICR, Neurology, Organic mental disorders. Neuropsychology, Peptide Fragments - antagonists & inhibitors, Peptide Fragments - toxicity, Plant Bark - chemistry, Plant Extracts - pharmacology, Psychology. Psychoanalysis. Psychiatry, Psychopathology. Psychiatry, Toxicology

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