Clinical breast cancer, 2015-02, Vol.15 (1), p.80-85
2015
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- Autor(en) / Beteiligte
- Titel
- BRCAness Predicts Resistance to Taxane-Containing Regimens in Triple Negative Breast Cancer During Neoadjuvant Chemotherapy
- Ist Teil von
- Clinical breast cancer, 2015-02, Vol.15 (1), p.80-85
- Ort / Verlag
- United States: Elsevier Inc
- Erscheinungsjahr
- 2015
- Quelle
- Elsevier ScienceDirect Journals
- Beschreibungen/Notizen
- Micro-Abstract We investigated BRCAness in the biopsy and surgical specimens from 73 patients with breast cancer, taken before and after taxane-containing neoadjuvant chemotherapy. All tumors that progressed on taxane-containing regimens had a poor prognosis; all had BRCAness and most were triple negative. Identifying BRCAness can help predict the response to taxane-containing regimens.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1526-8209eISSN: 1938-0666DOI: 10.1016/j.clbc.2014.08.003Titel-ID: cdi_proquest_miscellaneous_1645782708
- Format
- –
- Schlagworte
- Adult, Aged, Antineoplastic Combined Chemotherapy Protocols - therapeutic use, Carcinoma, Ductal, Breast - diagnosis, Carcinoma, Ductal, Breast - drug therapy, Carcinoma, Ductal, Breast - genetics, Carcinoma, Ductal, Breast - pathology, Drug Resistance, Neoplasm - genetics, Female, Genes, BRCA1, Genes, BRCA2, Hematology, Oncology and Palliative Medicine, Heterozygote, Humans, Middle Aged, Multiplex ligation-dependent probe amplification, Mutation, Neoadjuvant Therapy, Obstetrics and Gynecology, Platinum salts, Predictive marker, Prognosis, Prognostic marker, Retrospective Studies, Taxane resistance, Taxoids - administration & dosage, Triple Negative Breast Neoplasms - congenital, Triple Negative Breast Neoplasms - diagnosis, Triple Negative Breast Neoplasms - drug therapy, Triple Negative Breast Neoplasms - genetics, Triple Negative Breast Neoplasms - pathology