Details

Autor(en) / Beteiligte

• Wandeler, Gilles
• Gsponer, Thomas
• Bihl, Florian
• Bernasconi, Enos
• Cavassini, Matthias
• Kovari, Helen
• Schmid, Patrick
• Battegay, Manuel
• Calmy, Alexandra
• Egger, Matthias
• Furrer, Hansjakob
• Rauch, Andri

Titel

Hepatitis B Virus Infection Is Associated With Impaired Immunological Recovery During Antiretroviral Therapy in the Swiss HIV Cohort Study

Ist Teil von

• The Journal of infectious diseases, 2013-11, Vol.208 (9), p.1454-1458

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Hepatitis B virus (HBV) infection is a major cause of morbidity and mortality in human immunodeficiency virus (HIV)-infected patients worldwide. It is unclear whether HIV-related outcomes are affected by HBV coinfection. We compared virological suppression and immunological recovery during antiretroviral therapy (ART) of patients of different HBV serological status in the Swiss HIV Cohort Study. CD4 cell recovery during ART was significantly impaired in hepatitis B surface antigen-positive patients and in those with anti-hepatitis B core antigen alone compared with HBV-uninfected patients, despite similar virological efficacy of ART. CD4 increase in patients with resolved HBV infection was similar to that in HBV-uninfected individuals.