Details

Autor(en) / Beteiligte

• Méndez-Lagares, Gema
• Romero-Sánchez, M. Concepción
• Ruiz-Mateos, Ezequiel
• Genebat, Miguel
• Ferrando-Martínez, Sara
• Muñoz-Fernández, María Á.
• Pacheco, Yolanda M.
• Leal, Manuel

Titel

Long-Term Suppressive Combined Antiretroviral Treatment Does Not Normalize the Serum Level of Soluble CD14

Ist Teil von

• The Journal of infectious diseases, 2013-04, Vol.207 (8), p.1221-1225

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

2013

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Levels of soluble CD14 (sCD14) were longitudinally measured in 85 human immunodeficiency virus (HIV)—infected subjects during long-term receipt of suppressive combined antiretroviral therapy (cART) and compared to those in young and elderly HIV-negative control subjects. cART did not normalize sCD14 levels; rather, the HIV-infected group displayed a significantly higher sCD14 level at baseline (ie, before cART initiation), 1 year after cART initiation, and 5 years after cART initiation, compared with both control groups. Furthermore, the baseline CD4 + T-cell count was inversely associated with the baseline sCD14 level. Our results point to the necessity of complementary therapies to treat the activated/inflamed status associated with chronic HIV infection and to the benefits of early initiation of cART.