Sie befinden Sich nicht im Netzwerk der Universität Paderborn. Der Zugriff auf elektronische Ressourcen ist gegebenenfalls nur via VPN oder Shibboleth (DFN-AAI) möglich. mehr Informationen...
Patients Hospitalized With Laboratory-Confirmed Influenza During the 2010-2011 Influenza Season: Exploring Disease Severity by Virus Type and Subtype
Ist Teil von
The Journal of infectious diseases, 2013-10, Vol.208 (8), p.1305-1314
Ort / Verlag
Oxford: Oxford University Press
Erscheinungsjahr
2013
Quelle
Oxford Journals 2020 Medicine
Beschreibungen/Notizen
Background. The 2010-2011 influenza season was dominated by influenza A(H3N2) virus, but influenza A(H1N1) pdmO9 (pH1N1) and B viruses cocirculated. This provided an opportunity to explore within-season predictors of severity among hospitalized patients, avoiding biases associated with season-to-season differences in strain virulence, population immunity, and healthcare seeking. Methods. Population-based, laboratory-confirmed influenza hospitalization surveillance data were used to examine the association between virus type/subtype and outcomes in children and adults. Multivariable analysis explored virus type/subtype, prompt antiviral treatment, medical conditions, and age as predictors for severity (intensive care unit admission or death). Results. In children, pHlNl (adjusted odds ratio [aOR], 2.19; 95% confidence interval [CI], 1.11-4.3), chronic metabolic disease (aOR, 5.23; 95% CI, 1.74-15.69), and neuromuscular disorder (aOR, 4.84; 95% CI, 2.02-11.58) were independently associated with severity. In adults, independent predictors were pHlNl (aOR, 2.21; 95% CI, 1.66-2.94), chronic lung disease (aOR, 1.46, 95% CI, 1.12-1.89), and neuromuscular disorder (aOR, 1.68; 95% CI, 1. 11-2.52). Antiviral treatment reduced the odds of severity among adults (aOR, 0.47; 95% CI, .33-.68). Conclusions. During the 2010-2011 season, pHlNl caused more severe disease than H3N2 or B in hospitalized patients. Underlying medical conditions increased severity despite virus strain. Antiviral treatment reduced severity among adults. Our findings underscore the importance of influenza prevention.