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Occurrence and behavior of the chiral anti-inflammatory drug naproxen in an aquatic environment
Environmental toxicology and chemistry, 2014-12, Vol.33 (12), p.2671-2678
Suzuki, Toshinari
Kosugi, Yuki
Hosaka, Mitsugu
Nishimura, Tetsuji
Nakae, Dai
2014
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Suzuki, Toshinari
Kosugi, Yuki
Hosaka, Mitsugu
Nishimura, Tetsuji
Nakae, Dai
Titel
Occurrence and behavior of the chiral anti-inflammatory drug naproxen in an aquatic environment
Ist Teil von
Environmental toxicology and chemistry, 2014-12, Vol.33 (12), p.2671-2678
Ort / Verlag
Pensacola, FL: Blackwell Publishing Ltd
Erscheinungsjahr
2014
Quelle
Wiley-Blackwell Journals
Beschreibungen/Notizen
The present study reports on the occurrence and chiral behavior of the anti‐inflammatory drug (S)‐naproxen (NAP)—(S)‐2‐(6‐methoxynaphthalen‐2‐yl)propionic acid—in an aquatic environment under both field and laboratory conditions. In influents and effluents of sewage treatment plants (STPs) in the Tama River basin (Tokyo), (S)‐NAP was detected at concentrations of 0.03 µg L−1 to 0.43 µg L−1 and 0.01 µg L−1 to 0.11 µg L−1, respectively. The concentrations of a major metabolite, 6‐O‐desmethyl NAP (DM‐NAP) were up to 0.47 µg L−1 and 0.56 µg L−1 in influents and effluents, respectively. (R)‐naproxen was not detected in STP influents, although it was present in effluents, and the enantiomeric faction (= S/[S + R]) of NAP ranged from 0.88 to 0.91. Under laboratory conditions with activated sludge from STPs, rapid degradation of (S)‐NAP to DM‐NAP and chiral inversion of (S)‐NAP to (R)‐NAP were observed. During river die‐away experiments, degradation and chiral inversion of NAP were extremely slow. In addition, chiral inversion of (S)‐NAP to (R)‐NAP was not observed during photodegradation experiments. In the river receiving STP discharge, NAP and DM‐NAP concentrations reached 0.08 µg L−1 and 0.16 µg L−1, respectively. The enantiomeric faction of NAP in the river ranged from 0.84 to 0.98 and remained almost unchanged with the increasing contribution of rainfall to the river water. These results suggest that the absence and decrease of (R)‐NAP in river waters could indicate the inflow of untreated sewage. Environ Toxicol Chem 2014;33:2671–2678. © 2014 SETAC
Sprache
Englisch
Identifikatoren
ISSN: 0730-7268
eISSN: 1552-8618
DOI: 10.1002/etc.2741
Titel-ID: cdi_proquest_miscellaneous_1642296279
Format
–
Schlagworte
Activated sludge
,
Analytical chemistry
,
Anti-Inflammatory Agents - analysis
,
Anti-Inflammatory Agents - metabolism
,
Applied sciences
,
Aquatic environment
,
Biological and medical sciences
,
Biotechnology
,
Chiral inversion
,
Chromatography, High Pressure Liquid
,
Degradation
,
Drugs
,
Effluents
,
Enantiomeric fraction
,
Environment and pollution
,
Environmental Monitoring
,
Exact sciences and technology
,
Fundamental and applied biological sciences. Psychology
,
Industrial applications and implications. Economical aspects
,
Inflammation
,
Inflow
,
Influents
,
Inversion
,
Inversions
,
Laboratories
,
Metabolites
,
Miscellaneous
,
Naproxen
,
Naproxen - analysis
,
Naproxen - metabolism
,
Nonsteroidal anti-inflammatory drugs
,
Photodegradation
,
Photolysis
,
Pollution
,
Propionic acid
,
Rainfall
,
Receiving
,
River basins
,
Rivers
,
Rivers - chemistry
,
Sewage - chemistry
,
Sewage disposal
,
Sewage treatment
,
Sewage treatment plant
,
Sewage treatment plants
,
Stereoisomerism
,
Tandem Mass Spectrometry
,
Waste Disposal, Fluid
,
Waste treatment
,
Wastewater treatment
,
Wastewater treatment plants
,
Water Pollutants, Chemical - analysis
,
Water Pollutants, Chemical - metabolism
,
Water treatment and pollution
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