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Intravenous thrombolytic therapy is the only proven treatment for acute ischemic stroke, but its use is limited by a brief time window of up to 4.5 hours after the onset of symptoms
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and a recanalization rate of less than 50%. Large clots in vessels such as the distal internal carotid artery or the first segment of the middle cerebral artery respond poorly to intravenous thrombolysis.
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The need for a treatment for patients who do not have a good response to intravenous treatment alone remains pressing.
On the basis of compelling anecdotal experience, stroke specialists had hoped that transvascular recanalization would . . .