Details

Autor(en) / Beteiligte

• Özkan, Esin
• Özkan, Hüseyin
• Bilgiç, Serkan
• Odabaşi, Ersin
• Can, Nuray
• Akgül, Emin Özgür
• Yanmiş, Ibrahim
• Yurttaş Yüksel
• Kürklü, Mustafa
• Başbozkurt, Mustafa
• Erbil, Mehmet Kemal

Titel

Serum fetuin-A levels in postmenopausal women with osteoporosis

Ist Teil von

• Turkish journal of medical sciences, 2014, Vol.44 (6), p.985-988

Ort / Verlag

Turkey

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• One of the functions of fetuin-A is the restriction of formation and expansion ofextraosseous hydroxyapatite crystals. TIhe exact correlation of fetuin-A with bone mineral density (BMD) has not been clearly elucidated yet. In this study, we aimed to assess the relationship between BMD and fetuin-A in postmenopausal women. Fifty postmenopausal women (25 with osteoporosis, 25 healthy controls) were included in the study. All participants were comparable for age and body mass index. None of the osteoporotic patients had received any medical treatment for osteoporosis. Serum fetuin-A levels were measured by ELISA method. BMD scores of the groups were statistically significant (P < 0.001). Serum fetuin-A levels of the osteoporosis group were significantly lower compared to the control group (P = 0.009). Additionally, there was there was a mild to moderate positive correlation between fetuin-A and lumbar (r = 0.381, P = 0.06) and femoral (r = 0.143, P = 0.50) BMD in the osteoporotic group, though it did not reach statistical significance. Decreased fetuin-A levels in women with postmenopausal osteoporosis suggest that fetuin-A may have a role in the development of osteoporosis. Further studies are required to define the exact role of fetuin-A in bone metabolism.