Details

Autor(en) / Beteiligte

• Kim, Min Cheol
• Hwang, Eunson
• Kim, Taejung
• Ham, Jungyeob
• Kim, Sun Yeou
• Kwon, Hak Cheol

Titel

Nocatriones A and B, Photoprotective Tetracenediones from a Marine-Derived Nocardiopsis sp

Ist Teil von

• Journal of natural products (Washington, D.C.), 2014-10, Vol.77 (10), p.2326-2330

Ort / Verlag

United States: American Chemical Society and American Society of Pharmacognosy

Erscheinungsjahr

2014

Quelle

MEDLINE

Beschreibungen/Notizen

• Two new tetracenedione derivatives, nocatriones A (1) and B (2), were discovered from the culture broth of a marine actinomycete, Nocardiopsis sp. KMF-002, which was isolated from the tissue of an unidentified dark purple marine sponge. The structures of 1 and 2, which are tetracenediones containing α-pyrone substituents, were determined to be 3,8,10,11-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-5,12-dione (1) and 3,8,10,12-tetrahydroxy-2-(4-hydroxy-2-oxo-2H-pyran-6-yl)-1-methyltetracene-6,11-dione (2). Ultraviolet B (UVB)-irradiated cells treated with 10 μM nocatrione A (1) significantly decreased the level of MMP-1, a protein that degrades collagen and other extracelluar matrix components that comprise dermal tissue, when compared to untreated cells. These results support that nocatriones A (1) and B (2) may show antiphotoaging activity in UVB-irradiated models.