Details

Autor(en) / Beteiligte

• Morrison, Sandra G
• Farris, Christina M
• Sturdevant, Gail L
• Whitmire, William M
• Morrison, Richard P

Titel

Murine Chlamydia trachomatis Genital Infection Is Unaltered by Depletion of CD4 super(+) T cells and Diminished Adaptive Immunity

Ist Teil von

• The Journal of infectious diseases, 2011-04, Vol.203 (8), p.1120-1128

Erscheinungsjahr

2011

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Chlamydia muridarum and Chlamydia trachomatis mouse models of genital infection have been used to study chlamydial immunity and vaccine development. To assess the protective role of CD4 super(+) T cells in resolving C. trachomatis and C. muridarum genital tract infections, we used the female mouse model and evaluated infection in the presence and absence of CD4 super(+) T cells. In contrast to C. muridarum infection, C. trachomatis infection was unaltered in the absence of CD4 super(+) T cells. Mice infected with C. trachomatis developed protective immunity to re-challenge, but unlike C. muridarum infection, optimum resistance required multiple infectious challenges, despite the generation of adaptive serum and local chlamydial specific immune responses. Thus, understanding the chlamydial pathogenic and host immunologic factors that result in a diminished protective role for CD4 super(+) T cells in C. trachomatis murine infection might lead to new insights important to human immunity and vaccine development.