Details

Autor(en) / Beteiligte

• Seabra, Aline Damasceno
• Araújo, Taíssa Maíra Thomaz
• Mello Junior, Fernando Augusto Rodrigues
• Di Felipe Ávila Alcântara, Diego
• De Barros, Amanda Paiva
• De Assumpção, Paulo Pimentel
• Montenegro, Raquel Carvalho
• Guimarães, Adriana Costa
• Demachki, Samia
• Burbano, Rommel Mario Rodríguez
• Khayat, André Salim

Titel

High-density array comparative genomic hybridization detects novel copy number alterations in gastric adenocarcinoma

Ist Teil von

• Anticancer research, 2014-11, Vol.34 (11), p.6405-6415

Ort / Verlag

Greece

Erscheinungsjahr

2014

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• To investigate frequent quantitative alterations of intestinal-type gastric adenocarcinoma. We analyzed genome-wide DNA copy numbers of 22 samples and using CytoScan® HD Array. We identified 22 gene alterations that to the best of our knowledge have not been described for gastric cancer, including of v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4 (ERBB4), SRY (sex determining region Y)-box 6 (SOX6), regulator of telomere elongation helicase 1 (RTEL1) and UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 (B4GALT5). The most significant alterations related to peritoneal invasion involved the regions 13q21.1 (gain) and 15q15.1, 17q23.1, 19q13.2 and 20q11.22 (loss of heterozygozity; LOH), where we found LOH of erythrocyte membrane protein band 4.1-like 1 (EPB41L1) gene. In relation to early age of onset, the most significant alterations were gains in the regions Xq26 and Xp22.31 and a loss in the region 11p15.4. These quantitative changes may play a role in the development of this type of neoplasia and may be used as markers in evaluating poor prognosis, as well as act as potential therapeutic targets for gastric cancer.