Lung cancer (Amsterdam, Netherlands), 2014-12, Vol.86 (3), p.324-328
2014
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Gene mutations in small-cell lung cancer (SCLC): Results of a panel of 6 genes in a cohort of Italian patients
- Ist Teil von
- Lung cancer (Amsterdam, Netherlands), 2014-12, Vol.86 (3), p.324-328
- Ort / Verlag
- Oxford: Elsevier Ireland Ltd
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • We investigated the presence of mutations in a panel of 6 genes in 113 SCLCs. • We could identify only 7 mutations, 2 in EGFR and 5 in c-MET gene. • EGFR mutations seem to be related to female gender and low tobacco exposure. • c-MET mutations do not show any correlation with specific features. • Studies with c-MET and EGFR-directed therapies are warranted also in SCLC.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0169-5002eISSN: 1872-8332DOI: 10.1016/j.lungcan.2014.10.002Titel-ID: cdi_proquest_miscellaneous_1639496504
- Format
- –
- Schlagworte
- Adult, Aged, Aged, 80 and over, Biological and medical sciences, BRAF, c-KIT, c-MET, Disease-Free Survival, EGFR, Female, Gene Expression Regulation, Neoplastic, Gene mutations, Hematology, Oncology and Palliative Medicine, Humans, KRAS, Male, Medical sciences, Middle Aged, Molecular Targeted Therapy, Multiple tumors. Solid tumors. Tumors in childhood (general aspects), Mutation, PDGFRa, Pneumology, Proto-Oncogene Proteins - biosynthesis, Proto-Oncogene Proteins - genetics, Proto-Oncogene Proteins B-raf - biosynthesis, Proto-Oncogene Proteins B-raf - genetics, Proto-Oncogene Proteins c-kit - biosynthesis, Proto-Oncogene Proteins c-kit - genetics, Proto-Oncogene Proteins c-met - biosynthesis, Proto-Oncogene Proteins c-met - genetics, Proto-Oncogene Proteins p21(ras), Pulmonary/Respiratory, ras Proteins - biosynthesis, ras Proteins - genetics, Receptor, Epidermal Growth Factor - biosynthesis, Receptor, Epidermal Growth Factor - genetics, Receptor, Platelet-Derived Growth Factor beta - biosynthesis, Receptor, Platelet-Derived Growth Factor beta - genetics, SCLC, Small Cell Lung Carcinoma - drug therapy, Small Cell Lung Carcinoma - genetics, Small Cell Lung Carcinoma - pathology, Tumors, Tumors of the respiratory system and mediastinum