Details

Autor(en) / Beteiligte

• Kulkarni, AB
• Huh, Chang-Goo
• Becker, D
• Geiser, A
• Lyght, M
• Flanders, K C
• Roberts, AB
• Sporn, M B
• Ward, J M
• Karlsson, S

Titel

Transforming growth factor beta sub(1) null mutation in mice causes excessive inflammatory response and early death

Ist Teil von

• Proceedings of the National Academy of Sciences - PNAS, 1993-01, Vol.90 (2), p.770-774

Erscheinungsjahr

1993

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• To delineate specific developmental roles of transforming growth factor beta sub(1) (TGF- beta sub(1)) we have disrupted its cognate gene in mouse embryonic stem cells by homologous recombination to generate TGF- beta sub(1) null mice. Pathological examination revealed an excessive inflammatory response with massive infiltration of lymphocytes and macrophages in many organs, but primarily in heart and lungs. Many lesions resembled those found in autoimmune disorders, graft-vs.-host disease, or certain viral diseases. This phenotype suggests a prominent role for TGF- beta sub(1) in homeostatic regulation of immune cell proliferation and extravasation into tissues.