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In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale

Chemical reviews, 2022-05, Vol.122 (10), p.9497-9570

Theillet, Francois-Xavier

2022

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Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Chemical reviews, 2014-07, Vol.114 (13), p.6661-6714

2014

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Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Nature communications, 2016-01, Vol.7 (1), p.10251-10251, Article 10251

2016

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Real-time NMR monitoring of biological activities in complex physiological environments

Current opinion in structural biology, 2015-06, Vol.32, p.39-47

2015

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Sensitivity‐Enhanced 13C‐NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

Angewandte Chemie International Edition, 2020-06, Vol.59 (26), p.10411-10415

International ed. in English, 2020

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Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts

Nature protocols, 2013-07, Vol.8 (7), p.1416-1432

2013

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Cell signaling, post-translational protein modifications and NMR spectroscopy

Journal of biomolecular NMR, 2012-11, Vol.54 (3), p.217-236

2012

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In-cell NMR: Why and how?

Progress in nuclear magnetic resonance spectroscopy, 2022-10, Vol.132-133, p.1-112

2022

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Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

Nature structural & molecular biology, 2012-08, Vol.19 (8), p.819-823

2012

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Structural disorder of monomeric α-synuclein persists in mammalian cells

Nature (London), 2016-02, Vol.530 (7588), p.45-50

2016

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Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?

Biochemical Society transactions, 2012-10, Vol.40 (5), p.950-954

2012

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Affordable amino acid α/β-deuteration and specific labeling for NMR signal enhancement: Evaluation on the kinase p38α

Journal of Magnetic Resonance Open, 2023-12, Vol.16-17, p.100126, Article 100126

2023

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In-Cell Protein Structures from 2D NMR Experiments

The journal of physical chemistry letters, 2016-07, Vol.7 (14), p.2821-2825

2016

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Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines

Biochimica et biophysica acta, 2013-07, Vol.1834 (7), p.1396-1401

2013

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Power of Pure Shift HαCα Correlations: A Way to Characterize Biomolecules under Physiological Conditions

Analytical chemistry (Washington), 2020-09, Vol.92 (18), p.12423-12428

2020

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Structural dissection of amyloid aggregates of TDP‐43 and its C‐terminal fragments TDP‐35 and TDP‐16

The FEBS journal, 2020-06, Vol.287 (12), p.2449-2467

2020

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Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

Nature communications, 2020-04, Vol.11 (1), p.1819-1819, Article 1819

2020

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Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells

Nature chemical biology, 2014-12, Vol.10 (12), p.1000-1002

2014

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Thermodynamics of protein destabilization in live cells

Proceedings of the National Academy of Sciences - PNAS, 2015-10, Vol.112 (40), p.12402-12407

2015

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Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

Journal of molecular biology, 2020-12, Vol.432 (24), p.166689-166689, Article 166689

2020

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Sensitivity-Enhanced 13 C-NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

Angewandte Chemie International Edition, 2020-06, Vol.59 (26), p.10411-10415

2020

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Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners

Nucleic acids research, 2021-04, Vol.49 (7), p.3841-3855

2021

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Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C‑tail Revealed by NMR

Journal of the American Chemical Society, 2012-12, Vol.134 (50), p.20533-20543

2012

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Site-Specific Mapping and Time-Resolved Monitoring of Lysine Methylation by High-Resolution NMR Spectroscopy

Journal of the American Chemical Society, 2012-05, Vol.134 (18), p.7616-7619

2012

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NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time

ACS chemical biology, 2011-05, Vol.6 (5), p.419-424

2011

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In-Cell Structural Biology by NMR: The Benefits of the Atomic Scale

Physicochemical Properties of Cells and Their Effects on Intrinsically Disordered Proteins (IDPs)

Intracellular repair of oxidation-damaged α-synuclein fails to target C-terminal modification sites

Real-time NMR monitoring of biological activities in complex physiological environments

Sensitivity‐Enhanced 13C‐NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

Site-specific NMR mapping and time-resolved monitoring of serine and threonine phosphorylation in reconstituted kinase reactions and mammalian cell extracts

Cell signaling, post-translational protein modifications and NMR spectroscopy

In-cell NMR: Why and how?

Phosphorylation of histone H3 Ser10 establishes a hierarchy for subsequent intramolecular modification events

Structural disorder of monomeric α-synuclein persists in mammalian cells

Bacterial in-cell NMR of human α-synuclein: a disordered monomer by nature?

Affordable amino acid α/β-deuteration and specific labeling for NMR signal enhancement: Evaluation on the kinase p38α

In-Cell Protein Structures from 2D NMR Experiments

Quantitative NMR analysis of Erk activity and inhibition by U0126 in a panel of patient-derived colorectal cancer cell lines

Power of Pure Shift HαCα Correlations: A Way to Characterize Biomolecules under Physiological Conditions

Structural dissection of amyloid aggregates of TDP‐43 and its C‐terminal fragments TDP‐35 and TDP‐16

Proper chromosome alignment depends on BRCA2 phosphorylation by PLK1

Disorder and residual helicity alter p53-Mdm2 binding affinity and signaling in cells

Thermodynamics of protein destabilization in live cells

Megadalton-sized Dityrosine Aggregates of α-Synuclein Retain High Degrees of Structural Disorder and Internal Dynamics

Sensitivity-Enhanced 13 C-NMR Spectroscopy for Monitoring Multisite Phosphorylation at Physiological Temperature and pH

Di-phosphorylated BAF shows altered structural dynamics and binding to DNA, but interacts with its nuclear envelope partners

Ordered Phosphorylation Events in Two Independent Cascades of the PTEN C‑tail Revealed by NMR

Site-Specific Mapping and Time-Resolved Monitoring of Lysine Methylation by High-Resolution NMR Spectroscopy

NMR Profiling of Histone Deacetylase and Acetyl-transferase Activities in Real Time

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