Details

Autor(en) / Beteiligte

• Figueres, Marie-Lucile, MD
• Beaume, Julie, MD
• Vuiblet, Vincent, MD
• Rabant, Marion, MD
• Bassilios, Nader, MD
• Herody, Michel, MD
• Touchard, Guy, MD, PhD
• Noël, Laure-Hélène, MD

Titel

Crystalline light chain proximal tubulopathy with chronic renal failure and silicone gel breast implants: 1 case report

Ist Teil von

• Human pathology, 2015-01, Vol.46 (1), p.165-168

Ort / Verlag

United States: Elsevier Limited

Erscheinungsjahr

2015

Quelle

MEDLINE

Beschreibungen/Notizen

• Summary A 39-year-old female patient was admitted to explore chronic renal failure. Clinical history included silicone breast implants. Clinical examination was normal. Urinalysis revealed tubular proteinuria with Bence-Jones κ protein. Monoclonal immunoglobulin G κ and free monoclonal κ -light chains (LCs) were revealed by serum protein immunoelectrophoresis. Bone marrow aspiration with karyotype analysis and skeletal radiologic survey were normal. Kidney biopsy revealed a peculiar pattern of proximal tubular cells with hypertrophy and clarification initially diagnosed as an osmotic nephrosis. Immunofluorescence study, including immunoglobulin LCs conjugates was normal. Immunoelectron microscopy finally revealed a crystalline LC proximal tubulopathy κ. Our case presents some peculiarities: the absence of hematologic malignancy sign and the young patient's age. The silicone breast implants have been reported to be involved in the generation of monoclonal gammopathy.