Inorganic chemistry, 2014-12, Vol.53 (24), p.13105-13111
2014
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Details
- Autor(en) / Beteiligte
- Titel
- Synthesis, Structure, and Antiproliferative Activity of Ruthenium(II) Arene Complexes with N,O-Chelating Pyrazolone-Based β‑Ketoamine Ligands
- Ist Teil von
- Inorganic chemistry, 2014-12, Vol.53 (24), p.13105-13111
- Ort / Verlag
- United States: American Chemical Society
- Erscheinungsjahr
- 2014
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Novel ruthenium half-sandwich complexes containing (N,O)-bound pyrazolone-based β-ketoamine ligands have been prepared, and the solid-state structures of one ligand and five complexes have been determined by single-crystal X-ray diffraction. Some of the complexes display moderate cytotoxicity toward the human ovarian cancer cell lines A2780 and A2780cisR, the latter line having acquired resistance to cisplatin.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0020-1669eISSN: 1520-510XDOI: 10.1021/ic502274bTitel-ID: cdi_proquest_miscellaneous_1637551936
- Format
- –
- Schlagworte
- Amination, Antineoplastic Agents - chemistry, Antineoplastic Agents - pharmacology, Cell Line, Tumor, Chelating Agents - chemistry, Chelating Agents - pharmacology, Coordination Complexes - chemistry, Coordination Complexes - pharmacology, Crystallography, X-Ray, Drug Screening Assays, Antitumor, Female, Humans, Models, Molecular, Ovarian Neoplasms - drug therapy, Pyrazolones - chemistry, Pyrazolones - pharmacology, Ruthenium - chemistry, Ruthenium - pharmacology