Neuroscience, 2013-12, Vol.254, p.241-259
2013
Details
- Autor(en) / Beteiligte
- Titel
- Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway
- Ist Teil von
- Neuroscience, 2013-12, Vol.254, p.241-259
- Ort / Verlag
- United States: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights • An inhibitor of kynurenine-3-monoxygenase was administered to pregnant female rats. • Adult offspring at postnatal day 60 (P60) showed alterations in synaptic plasticity. • Expression of GluN2A, sonic hedgehog and other developmental proteins was changed. • Most earlier protein changes had disappeared with no changes in RNA or learning tasks. • Prenatal kynurenine pathway inhibition produces persistent synaptic and protein changes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2013.09.034Titel-ID: cdi_proquest_miscellaneous_1635035873
- Format
- –
- Schlagworte
- Age Factors, Animals, Brain - drug effects, Brain - growth & development, Brain - metabolism, doublecortin, Down-Regulation - drug effects, Down-Regulation - physiology, Excitatory Postsynaptic Potentials - drug effects, Excitatory Postsynaptic Potentials - physiology, Female, hedgehog, kynurenic acid, Kynurenine - antagonists & inhibitors, Kynurenine - biosynthesis, kynurenines, Male, neurodevelopment, Neurogenesis - drug effects, Neurogenesis - physiology, Neurology, Organ Culture Techniques, Pregnancy, Rats, Rats, Wistar, Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors, Receptors, N-Methyl-D-Aspartate - biosynthesis, Signal Transduction - drug effects, Signal Transduction - physiology, Sulfonamides - pharmacology, Synaptic Transmission - physiology, Thiazoles - pharmacology, tryptophan