Neuroscience, 2013-04, Vol.236, p.281-288
2013
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Details
- Autor(en) / Beteiligte
- Titel
- Icariin promotes histone acetylation and attenuates post-stroke cognitive impairment in the central cholinergic circuits of mice
- Ist Teil von
- Neuroscience, 2013-04, Vol.236, p.281-288
- Ort / Verlag
- Amsterdam: Elsevier Ltd
- Erscheinungsjahr
- 2013
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Highlights ► We examined the changes of central cholinergic circuits in post-stroke dementia mice. ► Icariin can improve the learning and memory damage in mice with post-stroke dementia. ► Icariin can restore the damage of histone acetylation in cholinergic circuits. ► Improved histone acetylation is likely due to the increase of CREB phosphorylation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0306-4522eISSN: 1873-7544DOI: 10.1016/j.neuroscience.2012.12.074Titel-ID: cdi_proquest_miscellaneous_1635024945
- Format
- –
- Schlagworte
- Acetylation, Acetylcholine - metabolism, Animals, Biological and medical sciences, Blotting, Western, Brain - drug effects, Brain - metabolism, cholinergic nerve circuits, Dementia - etiology, Dementia - metabolism, Disease Models, Animal, Flavonoids - pharmacology, Fundamental and applied biological sciences. Psychology, histone acetylation homeostasis, Histones - metabolism, ICA, Male, Maze Learning - drug effects, Medical sciences, Mice, Neural Pathways - drug effects, Neural Pathways - metabolism, Neurology, Neuroprotective Agents - pharmacology, phosphorylated CREB, post-stroke dementia, Reverse Transcriptase Polymerase Chain Reaction, Stroke - complications, Stroke - metabolism, Vascular diseases and vascular malformations of the nervous system, Vertebrates: nervous system and sense organs