Details

Autor(en) / Beteiligte

• Snider, Marlene
• Garg, Ravendra
• Brownlie, Robert
• van den Hurk, Jan V
• Hurk, Sylvia van Drunen Littel-van den

Titel

The bovine viral diarrhea virus E2 protein formulated with a novel adjuvant induces strong, balanced immune responses and provides protection from viral challenge in cattle

Ist Teil von

• Vaccine, 2014-11, Vol.32 (50), p.6758-6764

Ort / Verlag

Kidlington: Elsevier Ltd

Erscheinungsjahr

2014

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Highlights • BVDV E2 protein was formulated with a novel adjuvant as subunit vaccine. • This adjuvant consists of a polyphosphazene, poly(I:C) and a host defense peptide. • The E2 subunit vaccine elicited robust virus neutralizing antibody responses. • Calves vaccinated with the E2 subunit vaccine developed CD8+ cytotoxic T cell (CTL) responses. • The E2-vaccinated calves were protected from challenge with virulent BVDV-2.