Details

Autor(en) / Beteiligte

• Grell, M
• Becke, F M
• Wajant, H
• Maennel, D N
• Scheurich, P

Titel

TNF receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

Ist Teil von

• European journal of immunology, 1998-01, Vol.28 (1), p.257-263

Erscheinungsjahr

1998

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Tumor necrosis factor (TNF) mediates its biological effects by binding to two distinct but homologous receptor molecules. The type 1 receptor (TNF-R1) has been shown to be essential and sufficient for most cellular responses to soluble TNF. In contrast, only limited data exist concerning the role of the type 2 receptor (TNF-R2) in TNF responses, both in vitro and in vivo. Here, we demonstrate by the use of thymocytes from TNF-R-deficient mice that the TNF-R2-dependent enhancement of proliferation and secretion of granulocyte-macrophage colony-stimulating factor is in fact mediated by TNF-R2 on its own, independent of co-expression and/or stimulation of TNF-R1.