Details

Autor(en) / Beteiligte

• Roses, Allen D
• Lutz, Michael W
• Saunders, Ann M
• Goldgaber, Dmitry
• Saul, Robert
• Sundseth, Scott S
• Akkari, P. Anthony
• Roses, Stephanie M
• Gottschalk, W. Kirby
• Whitfield, Keith E
• Vostrov, Alexander A
• Hauser, Michael A
• Allingham, R. Rand
• Burns, Daniel K
• Chiba-Falek, Ornit
• Welsh-Bohmer, Kathleen A

Titel

African-American TOMM40'523- APOE haplotypes are admixture of West African and Caucasian alleles

Ist Teil von

• Alzheimer's & dementia, 2014-11, Vol.10 (6), p.592-601.e2

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2014

Link zum Volltext

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• Abstract Background Several studies have demonstrated a lower apolipoprotein E4 ( APOE ε4) allele frequency in African-Americans, but yet an increased age-related prevalence of AD. An algorithm for prevention clinical trials incorporating TOMM40'523 (Translocase of Outer Mitochondria Membrane) and APOE depends on accurate TOMM40'523- APOE haplotypes. Methods We have compared the APOE and TOMM40'523 phased haplotype frequencies of a 9.5 kb TOMM40/ APOE genomic region in West African, Caucasian, and African-American cohorts. Results African-American haplotype frequency scans of poly-T lengths connected in phase with either APOE ε4 or APOE ε3 differ from both West Africans and Caucasians and represent admixture of several distinct West African and Caucasian haplotypes. A new West African TOMM40'523 haplotype, with APOE ε4 connected to a short TOMM40'523 allele, is observed in African-Americans but not Caucasians. Conclusion These data have therapeutic implications for the age of onset risk algorithm estimates and the design of a prevention trial for African-Americans or other mixed ethnic populations.